 |  | Confirming Accurate Particle Counting and Sizing on
MFI Systems | [概要表示] |
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Polystyrene beads are ideal for particle sizing and sensitivity testing because they easily trigger the MFI imaging detector, yielding consistent and precise sizing and concentration results over a large size range. To ensure correct usage, this application note discusses recommended guidelines on how to use bead calibration for sizing and concentration verification on the MFI 5000 series with or without the Bot1 autosampler. |
| | Assess the Purity of Your Cell Therapy Product with Confidence: Micro-flow Imaging for Natural Killer Cell Therapeutics | [概要表示] |
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Differentiate between NK cells, its expansion components, and other subvisible particles with micro-flow imaging to ensure the purity of your cell therapeutic. |
| | Test More with Less Sample — Low Volume Particle
Analysis with MFI + Bot1 | [概要表示] |
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All biological therapeutics have to be tested for many quality attributes like protein aggregation. And all these quality attributes need to be tested at many different product development stages including early formulation, purification, manufacturing and QC. Add all those attributes and stages together and that's a lot of testing. It also means your sample is pretty precious given you often only have a few mLs to use per test — and that limits your ability to run replicates too. So to help stretch your sample to max out the amount of data you can collect, we looked at ways the automated MFI + Bot1 could decrease the amount of sample you need to get particle information on a whole bunch of sample concentrations.
In this application note, we’ll show you how to get the same great data you’ve always gotten with MFI, just with less than 600 μL of plated material instead of the usual 1.6 mL you’d normally use. |
| | Evaluating the Stability of Therapeutic Biosimilar Monoclonal Antibodies with Micro-Flow Imaging | [概要表示] |
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Particulate contamination, including protein aggregates, can have an effect on drug safety and efficacy, and characterization of subvisible particles can be an indicator of product and formulation stability. In this App Note, we show how we use Micro-Flow Imaging to evaluate the stability of two therapeutic monoclonal antibodies, trastuzumab and bevacizumab, and their biosimilars. |
| | Determining Residual Bead Count: Application of Micro-Flow Imaging to CAR T-Cell Manufacturing Application Note | [概要表示] |
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In this application note, you’ll see how automation via image-based Micro-Flow Imaging™ (MFI) technology gets you the quantitative and morphological data you need to have confidence in distinguishing between beads, T cells or other potential contaminants. |
| | MFI Silane-Coated Flow Cell Cleaning and Care Technical Note | [概要表示] |
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MFI Silane-Coated Flow Cell Cleaning and Care Technical Note |
| | Staying 21 CFR Part 11-Compliant with Micro-Flow Imaging View System Software and MFI Image Analysis | [概要表示] |
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In this application note, we’ll focus on the 21 CFR Part 11 tools integrated into MFI for method and batch execution, data processing
and audit trails. |
| | Automated Particle Analysis of Viscous Samples with
MFI and the Bot1 Autosampler | |
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| | Easy Particle Analysis for Viscous Samples with MFI | |
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| | Fast, Multi-sample Particle Analysis Using MVSS 4.0 | |
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| | More Efficiency with Equivalent Data: MFI 5200 Comparison to DPA 4200 | |
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| | Comparability Study of Manual and Automated
Particle Characterization with MFI | |
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