ProteinSimple Instruments Ella, Maurice, and Jess

From Your Peers

Get the lowdown directly from your peers! Read on to find out how scientists just like you are resolving their protein research.

Simple Western

Simple Western

Simple Western Systems are making waves in vaccine development, disease research, pharmaceutical development, and therapeutics.



iCE Systems

iCE Systems are optimizing method development with increased quality and speed leading to excellent results in biopharmaceuticals and QC labs.


Simple Plex

Simple Plex

Simple Plex Systems are on the front lines of COVID-19 and SARS-CoV-2 research along with detecting viral responses and biomarker quantification.


Single-Cell Western

Single-Cell Western

Single-Cell Western Systems are hard at work with heterogeneity analysis in Metastatic cell populations, stem cells, and single-cell expression heterogeneity.


MFI Systems

MFI Systems

MFI Systems are empowering biosimilar development and product quality with next level particle characterization.


FluorChem Systems

Fluorchem Systems

FluorChem Imagers are providing clearer insights into previously unseen changes in specific protein expression.


FluorChem Imagers

Narendra Sees More in His Immunoblots with the FluorChem Q Imager

"The FluorChem Q gives me clean and publication-quality results. This has helped me enormously to do accurate protein analysis which is very critical for preclinical validation of drugs."


Automated Capillary Electrophoresis: A Technological Renaissance at the Heart of Biopharmaceuticals

"I think that the data we produced [on Maurice] shows excellent quality, due to the precise and reliable Maurice instrument."

Joan Kicks Her Method Development into High Gear with iCE3

"The short run times and easy sample preparation allowed for method development within a day or two. The versatility of the instrument allows the possibility of offering clients rapid alternatives to traditional ID and charge heterogeneity assays."


Stephanie Gets the Whole Stability Profile of Therapeutic Molecules During Formulation Development with MFI

"MFI technology has allowed us to better understand what conditions promote stability of our therapeutic molecules, which ensures that only world-class medicines are delivered to patients."

Amber Raises the Bar on Product Quality with MFI

"We’re able to do extended analysis with images provided by MFI and then bridge this data with other techniques to identify and rapidly classify particles in solution. This helps our clients understand their products better and ensure they are providing the highest quality product to their patients."

Yuhwa's Biosimilars Analysis is a Slam-dunk with MFI + Bot1

"As a biosimilar company, we investigate whether our products are similar to reference material, and use the MFI to perform comparability and stability. We must test samples from a variety of sources... for all these samples, we chose the automated MFI with Bot1 because a manual-only system just wouldn't have enough throughput."

Simple Plex

Profiling Host Responses in COVID-19 Infections: Accelerating Biomarker Research with Ella

"A major advantage of Ella is that it’s very easy to use with virtually no maintenance, and it’s really fast. Simply dilute your sample and you’re ready to go—without the need for manual preparations that can take time and add user variability."

Dr. Leligdowicz Speeds Up the Transition of Pediatric Sepsis Biomarkers from Validation to the Clinic with Ella

"Ella allows us to rapidly quantify biomarkers from hundreds of cryopreserved samples and correlate them to specific outcomes. Now we’re ready to validate that what we identified in frozen plasma samples correlates to fresh blood samples taken at the point-of-care. Ella’s simplicity and reproducibility will allow us to reliably test samples across different sites, enhancing triage especially in remote locations of developing countries where access to trained healthcare professionals is unlikely."

Ella Promises Better Clinical Care for Acute Respiratory Failure and Sepsis

"There is enormous potential value for applying Ella in a personalized medicine setting."

Characterizing T-cell Immune Responses Against SARS-CoV-2 with Ella

"Ella is a simple and fast immunoassay platform that would be ideal for implementation in higher biosafety facilities, like BSL-3, to study the acute phase of SARS-CoV-2 infection."

Simplifying and Expediting Inflammatory Biomarker Research with Ella

"Ella is the closest I’ve seen to my goal of one day having a Star Trek-like tricorder. I can take just 25 μL of serum, add it to a cartridge, and in 90 minutes have immune profiling data."

Angiogenesis and the Search for Novel Biomarkers

"Ella allows for reproducible sample data with minimal sample input. The lower volume usage allows for the expansion of research into novel areas of angiogenesis and inflammation as they pertain to many forms of cancer."

Paulomi Fast-tracks Detection of Viral Responses During Pregnancy with Ella

"Simple Plex assays on Ella gave us speed and efficiency so we could complete our assays quickly, and the high quality of the data meant that we could easily see differences between disease state samples and controls. Plus, sample preparation was so simple it reduced chances of errors significantly."

Simple Western

Utilizing Simple Western to Understand Neuronal Markers in Schizophrenia

"It can be difficult to optimize new antibodies, particularly for brain markers where you have a lot of background noise and low levels of your target. The appropriate control and low variability between plates using Simple Western™ means we can complete our studies in weeks rather than months."

Delving into the Complexities of Endometrial Receptivity with Simple Western

"Our lab came across ProteinSimple’s Simple Western platforms in 2014 and was surprised by the sensitivity and specificity of the technology, as well as its minimal usage of consumables"

Investigating Resolution of Inflammation with Jess

"Jess is a user-friendly, multi-purpose platform that gives me the possibility to perform Western blot analysis on precious samples, as well as quantifying proteins expressed in the cells at the same time."

Muhammad Uses Simple Western to Chart Signaling Pathways in Stem Cells

"Protein analysis using [Simple Western] can be performed faster, eliminating tedious work and saving time."

Elena Unlocks Immune Cell Potential with Simple Western and CRISPR/Cas9

"I used Simple Western because the protein samples I had were small. We only had a small number of [iPSC-derived macrophages] because the cell line does not proliferate."

Targeting Once Inaccessible Phospho-Proteins with RePlex

"By switching my assays over to Simple Western, I am able to increase my throughput, allowing for full dose responses to be generated in each experiment. Utilizing the RePlex module even further increases this throughput as I often probe for 5-6 proteins per capillary in a single run including phosphorylated/total protein pairs in the same lane."

Unraveling Neurodegenerative Diseases with Jess

"It saves so much time! It takes away so much of the pipetting and manipulation error. You just load your samples and wait for results, and in the meantime, you can dedicate yourself to other activities."

Conducting Novel Therapeutics Research of Human Gliomas with Jess

"Jess allows me to reduce the preparation time, save on reagents, samples, and antibodies, while allowing easier optimization of target proteins/antibodies. Jess’s ability to detect multiple proteins per sample further saves time compared to conventional Western blot."

Jess Breaks New Quantitative Ground in New Chemical Entity Screening at TCG Lifesciences

"The quantitative assays and short run times on Jess enable us to generate data faster and be more confident in our results."

PROTAC® Studies Take Off in Drug Discovery, and Jess is on Board

"I work for a fast-paced drug discovery CRO where our clients expect high-quality data with rapid turnarounds. Jess allows me to accurately assess drug compound potency, and with its high throughput ability I can screen multiple compounds quickly and efficiently."

Rebel without a Cause - Searching for the Origins of Parkinson's Disease with Wes

"It’s had a significant impact on our research... we get double the amount of data in a third of the time."

Simple Western and the Race to Develop a Vaccine for the COVID-19 Coronavirus

"Simple Western allowed me to screen quickly lots of samples with different antibodies while eliminating the manual washing and incubation steps."

Wes Validates the Potential of RNA-based Metabolic Therapies At MiNA Therapeutics

"I can run immunoassays on Wes for an entire animal experiment in a single day. This is something I wouldn’t even try with traditional Western blots."

Wes Zips Through Pharmacodynamic Biomarker Discovery Projects at the University of Glasgow

"I was able to screen various antibodies in a single run within half a day. This had previously taken weeks and months using traditional Western blotting methods."

Quantifying Protein Phosphorylation in Platelets with Wes

"[Wes] Provides quantitative data, saves time and uses far less sample."

Lower Limit of Detection Advances Understanding of Metabolic Signaling in Human Muscle

"Wes allows us to measure cell signaling proteins from a single muscle fiber segment by lowering our limit of detection nearly ~20-fold from Western blotting. It also allows for much more precise, reproducible, and faster results to be generated, in addition to far greater ease of operation, analysis, and waste disposal."

Detecting Low Abundance Proteins in Precious Pediatric Cancer Samples with Wes

"Some of the proteins we wanted to detect are low in abundance and it’s really hard to get a good amount of protein for traditional Western blot. The low protein concentrations required by Wes makes it easier to save precious samples ensuring protein detection."

Jane Gets Fast Answers for Cancer Research with Wes

"Wes is easy to use, convenient, and gives answers quickly. The throughput and system automation is a definite advantage."

Melyssa Speeds Up the Core with Wes

"We’ve been able to increase productivity dramatically with Wes. The results are much better too, given that it removes the blotting step all together."

Kazuya Takes on Far-Western Blotting to Detect Protein Phosphorylation with Wes

"The no-gel, no-transfer, no-membrane features are beneficial for the reproducibility of the assay. I really like this system over traditional Western."

Emma Gets to Better Outcomes for Osteoarthritis Patients with Wes

"Wes gives me more throughput so I can get more replicates and trust my results a little bit more, and I can trust them straight away rather than having to do a lot of repeats. And obviously I like getting results the same day rather than having to wait two days"

Mary Makes More Links Between Obesity and Cancer with NanoPro 1000

"The Simple Western Charge assay, a capillary isoelectric focusing immunoassay, exceeded the reliability of 2D Western blots for resolving recombinant PKG-Iα and PKG-Iβ and uses 100,000X less sample quantity, making it well-suited for clinical disease proteomics because protein isoforms and post-translational modifications can be detected in precious tissue biopsies."

Jamie Keeps Things Greener with Wes

"The traditional blotting method can use up to 300 pieces of plastic and Wes uses two. What's even better is that Wes can run up to 40 proteins in three days. It would take about a week to run 40 proteins using Western blotting."

Brian Cuts Time to Results and Solves His Membrane Protein Challenges with Wes

"We had been trying to study receptor proteins with traditional Westerns but it was frustrating—we just could not get it. A few months with Wes and we've already had way more success than we had in three years."

Miranda Sets a New Pace for Alzheimer's Research with Wes

"The rapid, reproducible results on small amounts of tissue/cell lysates have allowed me to generate a more thorough data set on additional proteins, samples, conditions and brain regions all in the same amount, or even less time, as traditional Western blot. This technology has made it possible for small research labs to compete with the pace that research is conducted in large labs or companies."

Mary Ups Her Data Point Count on Laser Capture Microdissection Samples with Wes

"We collect samples from laser microdissection and were using our entire sample on just one regular Western blot. With Wes, we can do multiple assays with one sample collection."

Noelle Changes Her Brain Receptor Research Game with Wes

"One of the best advantages of using Wes is that it saves a lot of time, both in terms of hands-on time and in time to completion of the experiment. We were spending more than 4 hours of hands-on time per Western blot with traditional methods, and we can set up a run on the Wes in about 45 minutes. Our Wes runs are completed in less than 4 hours, as opposed to 4 days with traditional methods."

Single-Cell Western

Milo Goes Keto: Conquering Analysis of Scarce Intestinal Stem Cell Populations

"With Milo, we observed a level of single-cell protein expression heterogeneity in our purified intestinal stem cell population that was not previously possible with conventional Western blotting."

Guts and Glory: Validating a Neuroepithelial Circuit using Milo

"We have been pairing Milo with single-cell real time qPCR data. We have the RNA and we know the transcripts are present. We used Milo to confirm our results and quantify the amount of protein that is in each individual cell."

Dr. Zhong & Colleagues Understand Heterogeneity in Metastatic Cell Populations with Milo

"Milo permits study of proteins at the single-cell level to understand the heterogeneity among metastatic cells within a population."

Prashant Gets a Better Picture of Taxane Resistance at the Single-Cell Level with Milo

"I was looking at two different isoforms of a protein, and it was important to know if the cells were expressing just one versus the other or both in a given cell. That was tricky until Milo came. We’re also getting more relevant information because Milo allows us to look at expression of this protein in tissue biopsies."